The compound CFE1 (Hyperoside) was isolated from EtOAc extract of Cratoxylum formosum Dyer., together with studies proving the presence of genipin, geniposide, crocetin in Gardenia Jasminoides Ellis. and huperzin A in Lycopodium cernuum L. These compounds have valuable biological activities such as anti-inflammatory, antioxidant, blood activator, treatment of atherosclerosis, and other cardiovascular diseases. Therefore, hard capsules have been prepared from 3 materials, helping to support the treatment of cardiovascular diseases. In addition, hard capsules have been successfully prepared from 3 materials with physico-chemical criteria such as the uniformity of the capsule's mass, disintegration, content of moisture, ash. The standards of capsule preparation followed the regulations of the Ministry of Health and Vietnamese Pharmacopoeia IV. Thereby, it has opened up new directions of research to use 3 these materials in supplements and drugs to support the treatment of other cardiovascular diseases.

Keywords: Cratoxylum formosum Dyer., Gardenia Jasminoides Ellis., Lycopodium cernuum L., Hyperoside, hard capsule, cardiovascular diseases.